40. San Juan, J. A., Chakarawet, K., He, Z., Harder, N. H. O., Fernandez, R. L. Stevenson, M. J., Janisse, S. E., Wang, L., Britt, R. D., Heffern, M. C.* Copper(II) affects the activity of proinsulin C-peptide by forming ternary complexes with serum albumin. J. Am. Chem. Soc. 2023, 145, 30, 16726–16738. DOI:

39. Janisse, S. J., Fernandez, R. L., Heffern, M. C.* Emerging Applications of Mass Spectrometry to Metal-Interacting Biomolecules. Trends Biochem. Sci. 2023, 48, 9, 815-825. DOI:

38. Lee, V..J., Janisse, S.E., Heffern, M. C.* Plant-derived chelators and ionophores as potential therapeutics for metabolic disease. Chem. Soc. Rev. 2023, 52, 3927-3945. DOI:

37. Sarode, G. V., Mazi, T. A., Neier, K., Shibata, N. M., Jospin, G., Harder, N. H. O., Heffern, M. S., Sharma, A. K., More, S. K., Dave, M., Schroeder, S. M., Wang, L., LaSalle, J. M., Lutsenko, S., Medici, V. The role of intestine in metabolic dysregulation in murine Wilson disease. bioRxiv 2023.; In Press in Hepatol. Commun.

36. O’Sullivan, J. J.‡, Uyeda, K. S.‡, Stevenson, M. J., Heffern, M. C.* Investigation of metal modulation of oxytocin structure receptor-mediated signaling. RSC Chem. Biol. 2023, 4, 165-172. DOI:

35. O’Sullivan, J. J., Lee, V. J., Heffern, M. C.* Copper-mediated oxidation of imidazopyrazinones inhibits marine luciferase activity. Luminescence. 2023, 38, 216-220. DOI: https:/. /

34. Medici, V., Heffern, M.C. Monitoring and treatment of Wilson disease: progress and challenges. Lancet Gastroenterol. Hepatol. 2022, 7, P1063-1065. (Commentary)

33. Lee, V. J., Heffern, M. C.* Structure-activity assessment of flavonoids as modulators of copper transport. Front. Chem., 2022, 10, 972198. DOI:

32. Janisse, S. E., Sharma, V. A., Caceres, A., Medici, V., Heffern, M. C.* Systematic Evaluation of Copper(II)-Loaded Immobilized Metal Affinity Chromatography for Selective Enrichment of Copper-Binding Species in Human Serum and Plasma. Metallomics, 2022, 14, mfac059. DOI:

31. O’Sullivan, J. J., Heffern, M. C.* Development of an ATP-independent bioluminescent probe for detection of extracellular hydrogen peroxide. Org. Biomol. Chem. 2022, 20, 6231-6238. DOI:

30. Harder, N. H. O., Lee, H. P., Flood, V. J., San Juan, J. A., Gillette, S. K., Heffern, M. C.* Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper. Front. Mol. Biosci., 2022, 9, 863296. DOI:

29. Choi, S., San Juan, J. A., Heffern, M. C., Stevenson, M. J.* Quantifying the Binding Interactions between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores. J. Vis. Exp. 2022, 182, e63668. DOI: https://doi:10.3791/63668

28. O’Sullivan, J. J., Medici, V., Heffern, M. C.* A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper(II). Chem. Sci. 2022, 13, 4352-4363. DOI:

27. Hussein, F. A., Janisse, S. E., Heffern, M. C., Kinyua, M., Velazquez, J. M. Adsorption of Perfluorooctanoic Acid from Water by pH-modulated Brönsted Acid and Base Sites in Mesoporous Hafnium Oxide Ceramics. iScience. 2022, 25, 104138. DOI:

26. Harder, N. H. O., Hieroniumus, B., Stanhope, K. L., Shibata, N. M., Lee, V., Nunez, M. V., Keim, N. L., Bremer, A., Havel, P. J., Heffern, M. C.*, Medici, V.* Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans. Nutrients 2020, 12, 2581.

25. Olugbeminiyi, O. F., Heffern, M. C., Sanders Johnson, S., Townsend, S. D. What Comes Next? Simple Practices to Improve Diversity in Science. ACS Cent. Sci. 2020, 6, 1231-1240. DOI: (Editorial)

24. O’Sullivan, J. J., Harder, N. H. O., Heffern, M. C.* Detecting liver disease via an endogenous pigment. Nat. Biomed. Eng. 2020, 4, 761–762. (News & Views)

23. Stevenson, M. J., Janisse, S. E., Tao, L., Neil, R. L., Pham, Q. D., Britt, R. D., Heffern, M. C.* Elucidation of a Copper Binding Site in Proinsulin C-peptide and Its Implications for Metal-Modulated Activity. Inorg. Chem., 2020, 59, 9339–9349.

22. Stevenson, M. J., Farran, I. C., Uyeda, K. S., San Juan, J. A. Heffern, M. C.* Analysis of metal effects on C‐peptide structure and internalization. ChemBioChem, 2019, 20, 2447 –2453.

21. Baldari, S., Di Rocco, G., Heffern, M. C., Su, T. A., Chang, C. J., Toietta, G. Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells. Cancer, 2019, 11, 659.

20. Juttukonda, L. J., Green, E. R., Lonergan, Z. R., Heffern, M. C., Chang, C. J., Skaar, E. P. Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide. Infect. Immun.2019, 87, e00413-18.

19. Stevenson, M. J.†, Uyeda, K. S.†, Harder, N. H., Heffern, M. C.* Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology. Metallomics, 2019, 11, 85-110.

18. Su, T. A., Shihadih, D., Cao, W., Detomasi, T., Heffern, M. C., Jia, S., Stahl, A., Chang, C. J. A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. J. Am. Chem. Soc.2018, 140, 13764-13774.

17. Stevenson, M. J., Heffern, M. C.* Sounding out dysfunctional oxygen metabolism: a small-molecule probe for photoacoustic imaging of hypoxia. Biochemistry2018, 57, 893-894. (Commentary)

16. Heffern, M. C.* Diversifying the Glowing Bioluminescent Toolbox. ACS Cent. Sci., 2017, 3, 1234-1236. (First Reactions)

15. Aron, A. T.,† Heffern, M. C.,† Lonergan, Z. R,† Vander Wal, M. N., Baker, B. R.,† Spangler, B., Zhang, Y., Park, H., Stahl, A., Renslo, A. R., Skaar, E. P., Chang, C. J. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc. Natl. Acad. Sci., 2017, 114, 12669-12674.

****Prior to 2017****
14. Heffern, M.C., Park, H., Au-Yeung, H., Van de Bittner, G. C., Ackerman C. M.; Stahl, A., Chang, C. J. In vivo bioluminescence reveals copper deficiency in a murine model of non-alcoholic fatty liver disease. Proc. Natl. Acad. Sci., 2016, 113, 14219-14224.

13. Heffern, M.C., Reichova, V., Coomes, J. L., Harney, A. S., Bajema, E.; Meade, T. J. Tuning Cobalt(III) Schiff Base Complexes as Activated Protein Inhibitors. Inorg. Chem., 2015, 18, 9066-74.

12. Heffern, M. C., Velasco, P. T., Matosziuk, L. M., Coomes, J. L., Karras, C., Eckermann, A. L., Klein, W. B., Meade, T. J. Modulation of Amyloid-β Oligomerization by Co(III) Schiff Base Complexes. ChemBioChem, 2014, 15, 1584-1589.

11. Heffern, M. C., Matosziuk, L. M., Meade, T. J. Lanthanide Probes for Bioresponsive Imaging. Chem. Rev.2014, 114, 4496-4539.

10. Heffern, M. C.; Kurutz, J.; Meade, T. J. Spectroscopic Elucidation of the Inhibitory Mechanism of Cys2His2 Zinc Finger Transcription Factors by Cobalt(III) Schiff Base Complexes. Chem. Eur. J., 2013, 19, 17043-17053.

9. Heffern, M. C.; Yamamoto, N.; Holbrook, R. J.; Eckermann, A. E.; Meade, T. J. Cobalt Complexes as Promising Therapeutic Agents. Curr. Opin. Chem Biol. 2013, 17, 189-196.

8. Matosziuk, L.M.; Leibowitz, J. H.; Heffern, M. C.; Macrenaris, K. W.; Ratner, M. A.; Meade, T. J. Structural Optimization of Zn(II) Activated MR Imaging Probes. Inorg. Chem., 2013, 52, 12250-12261.

7. Manus, L. M.; Holbrook, R. J.; Atesin, T. A.; Heffern, M. C.; Harney, A. S.; Eckermann, A. E.; Meade, T. J. Axial Ligand exchange of N-heterocyclic Cobalt(III) Schiff Base Complexes: Molecular Structure and NMR Solution Dynamics. Inorg. Chem., 2013, 52, 1069-1076.

6. Matosziuk, L. M.; Holbrook, R. J.; Manus, L. M.; Heffern, M. C.; Ratner, M. A.; Meade, T. J. Rational Design of [Co(acacen)L2]+ Inhibitors of Biological Activity. Dalton Trans., 2013, 42, 4002-12.

5. Velasco, P. T.; Heffern, M. C.; Sebollela, A.; Popova, I. A.; Lacor, P. N.; Lee, K. B.; Zun, X.; Tiano, B. N.; Viola, K. L.; Eckermann, A. L.; Meade, T. J; Klein, W. L. Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies. ACS Chem. Neurosci., 2012, 3, 972-981.

4. Hurtado, R.; Harney, A. S.; Heffern, M. C.; Holbrook, R. J.; Holmgren, R.; Meade, T. J. Specific inhibition of the transcription factor Ci by a Cobalt(III)-Schiff base-DNA conjugate. Mol. Pharm., 2012, 9, 325-333.

3. Beier, C. W.; Cuevas, M. A.; Brutchey, R. L. Low-Temperature Synthesis of Solid-Solution BaxSr1-xTiO3 Nanocrystals. J. Mater. Chem., 2010, 20, 5074-5079.

2. Beier, C. W.; Cuevas, M. A.**; Brutchey, R. L. Effect of Surface Modification on the Dielectric Properties of BaTiO3 Nanocrystals. Langmuir, 2010, 26, 5067-5071.

1. Beier, C. W.; Cuevas, M. A.**; Brutchey, R. L. Room-Temperature Synthetic Pathways to Barium Titanate Nanocrystals. Small, 2008, 4, 2102-2106.

* Corresponding authorship by M.C.H.
† Denotes equal contribution
**Maiden name: Cuevas, M. A.