The endocrine system coordinates organ function and homeostasis by sending chemical messengers, or hormones, from endocrine glands to target tissues. We will take a multidisciplinary approach to uncover the roles and applications of metals in the endocrine system in an area that we term metalloendocrinology. We will perform research at the interface of bioinorganic chemistry, analytical chemistry, chemical biology, and metabolic biology to investigate the interactions between metals and the endocrine system from the molecular level to the whole animal. With a diverse approach we seek to gain insight and develop therapeutic solutions to endocrine disorders spanning diabetes, liver disease, and cancer.